Neuromuscular function after muscle fatigue in Charcot-Marie-Tooth type 1A patients

作者：Menotti Federica; Bazzucchi Ilenia; Felici Francesco; Damiani Antonello; Gori Maria Cristina; Macaluso Andrea^*

来源：Muscle & Nerve, 2012, 46(3): 434-439.

DOI：10.1002/mus.23366

• hereditary neuromuscular disorders
• maximal voluntary contraction
• muscle-fiber conduction velocity
• neuropathies
• surface electromyography

Introduction: The effect of recovery time on neuromuscular function after a fatiguing task was compared in both the upper and lower limbs between patients with CharcotMarieTooth type 1A (CMT1A) and healthy individuals. Methods: Torque of elbow flexors and knee extensors and surface electromyography (sEMG) data of biceps brachii and vastus lateralis were recorded from 8 CMT1A patients and 8 matched, healthy individuals during maximal voluntary contraction (MVC) before (pre-fatigue MVC), 10 s after (10-s post-fatigue MVC), and 10 min after (10-min post-fatigue MVC) a fatiguing task at 80% MVC until exhaustion. Results: Only in the lower limb, torque and root mean square of sEMG (RMS) during pre-fatigue MVC were lower (P < 0.05) in patients (91.93 +/- 45.95 Nm, 0.11 +/- 0.07 mV) than in controls (161.06 +/- 75.5 Nm, 0.24 +/- 0.16 mV). In the 10-min post-fatigue MVC, muscle-fiber conduction velocity (MFCV) and RMS, expressed as a percentage of pre-fatigue MVC, were lower (P < 0.05) in patients (MFCV 90.3 +/- 6.91%, RMS 84.50 +/- 9.89%) than in controls (MFCV 100.87 +/- 5.1%, RMS 92.71 +/- 11.84%). Conclusions: CMT1A patients are not only weaker than healthy individuals in the knee extensors, but they also have impaired neuromuscular recovery after fatigue. Muscle Nerve 46: 434439, 2012

• 出版日期2012-9