A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration

作者：Sato Yosinori; Yang Ping; An Ying; Matsukawa Kazushige; Ito Kikukatsu; Imanishi Shigeo; Matsuda Hirokazu; Uchiyama Yusuke; Imai Kunio; Ito Shigeki; Ishida Yoji; Suzuki Koichi^*

来源：Peptides, 2010, 31(5): 827-833.

DOI：10.1016/j.peptides.2010.02.017

• Insect pentapeptide
• Yamamarin compound
• Cell growth arrest
• Mitochondrial respiration arrest
• Biopharamaceutical

A palmitoyl conjugate of an insect pentapeptide that occurs in diapausing insects causes a reversible cell-cycle arrest and suppresses mitochondrial respiration. This peptide compound also causes growth arrest in murine leukemic cell line expressing human gene Bcr/Abl and a farnesoyl peptide induces embryonic diapause in Bombyx mori. These results demonstrate that the insect peptide compounds can lead to the understanding of a common pathway in developmental arrest in animals and may provide a new peptidominetic analog in the development of biopharmaceuticals and pest management.

• 出版日期2010-5