Urea Transporter Inhibitors: En Route to New Diuretics

作者:Sands Jeff M*
来源:Chemistry & Biology, 2013, 20(10): 1201-1202.
DOI:10.1016/j.chembiol.2013.10.003

摘要

A selective urea transporter UT-A1 inhibitor would be a novel type of diuretic, likely with less undesirable side effects than conventional diuretics, because it acts on the last portion of the nephron. In this issue of Chemistry & Biology, Esteva-Font and colleagues develop such an inhibitor by using a clever high-throughput screening assay and document its selectivity.

  • 出版日期2013-10-24