科研之友
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摘要
Objective: The postoperative PCIA effects of dezocine in elderly patients were determined using a large multicenter randomized double-blind prospective study. Methods: A total of 279 patients were randomized into four groups: (1) Control group (C): 2 mu g/kg sufentanil plus 10 mg metoclopramide. (2) Dezocine group 1 (D1): 1 mu g/kg sufentanil plus 0.1 mg/kg dezocine plus 10 mg metoclopramide. (3) Dezocine group 2 (D2): 1 mu g/kg sufentanil plus 0.2 mg/kg dezocine plus 10 mg metoclopramide. (4) Dezocine group 3 (D3): 1 mu g/kg sufentanil plus 0.3 mg/kg dezocine plus 10 mg metoclopramide. The index during operation including MAP, HR, SpO(2), ETCO2, CVP, and BIS were determined. Analgesia effects including HR, MAP, RR, SpO(2), pressing times of PCA demand, pressing times of PCR delivery, total amount of drug, additional sufentanil, VAS at rest and during moving, Ramsay sedation score, and BCS were repeated measured 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. Overall satisfaction index and the side-effects including nausea, urinary retention, skin pruritus and respiratory depression were evaluated 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. Results: Dezocine combining with sufentanil is complement for sufentanil in PCIA at least in its analgesia effects after surgery. Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg combining with sufentanil (1 mu g/kg) has limited side effects as sufentanil (2 mu g/kg) in PCIA. Sufentanil (1 mu g/kg) combining Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg is better than combining Dezocine at a dosage of 0.3 mg/kg in PCIA at least in Overall satisfaction index. Conclusion: Dezocine combining with sufentanil is a complement drug for sufentanil in PCIA. Considering the side effects and overall satisfaction index, 0.1 mg/kg seems to be an ideal dosage for Dezocine using in the postoperative PCIA in elderly patients.
- 出版日期2014
- 单位上海交通大学; 上海市徐汇区大华医院; 上海市浦东新区人民医院
