The Routine Clinical use of Pharmacogenetic Tests: What it Will Require?

作者：Dias Mafalda M; Sorich Michael J; Rowland Andrew; Wiese Michael D; McKinnon Ross A^*

来源：Pharmaceutical Research, 2017, 34(8): 1544-1550.

DOI：10.1007/s11095-017-2128-0

• biomarkers
• clinical uptake
• diagnostic tests
• personalized medicine

Pharmacogenetic testing aims to personalize drug therapy with a view to optimising drug efficacy and minimise toxicity. However, despite the potential benefits, pharmacogenetic testing is mostly confined to specialised medical areas, laboratories and centres. Widespread integration into routine clinical practice has been limited by a complex set of issues including regulatory and reimbursement frameworks, evidence of clinical utility and clinician perspectives, practices and education. Here we assess the current barriers to widespread clinical uptake and identify the key issue necessary to address to accelerate routine testing.

• 出版日期2017-8