alpha-Synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation

作者：Wang Chengshan; Shah Nilam; Thakur Garima; Zhou Feimeng^*; Leblanc Roger M

来源：Chemical Communications, 2010, 46(36): 6702-6704.

DOI：10.1039/c0cc02098b

alpha-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of alpha-synuclein.

• 出版日期2010