科研之友
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摘要
The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl. trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm(3), the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 mu g/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.
- 出版日期2014-12
- 单位中南大学
