A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord: The effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats

作者：Morizane Kei; Ogata Tadanori^*; Morino Tadao; Horiuchi Hideki; Yamaoka Gotaro; Hino Masayuki; Miura Hiromasa

来源：Neuroscience Research, 2012, 72(3): 279-282.

DOI：10.1016/j.neures.2011.12.003

• Mild hypothermia
• Microglia
• Spinal cord
• Behavior
• Local cooling
• TNF-alpha

We developed a novel thermoelectric cooling device using Peltier modules for the treatment of spinal cord injury in rats. The extracorporeal electrically cooling component was attached to the aluminum arched plate which was placed on the surface of the spinal cord after the contusion injury in the 11th thoracic spinal cord. During the hypothermic treatment, rats were awake and could move in the cage. Hind limb motor function, evaluated using a BBB scale, in the hypothermic animals (33 degrees C for 48 h) was significantly higher than that in the normothermic animals from 2 weeks to 8 weeks after the injury.

• 出版日期2012-3