First theophylline-based ratiometric fluorescent synthetic receptor for selective recognition of dihydrogenphosphate and biological phosphate ions

作者：Mahapatra Ajit K^*; Hazra Giridhari; Sahoo Prithidipa

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(3): 1358-1364.

DOI：10.1016/j.bmcl.2011.12.075

• Theophylline
• Fluorescent chemosensor
• Ratiometric
• Dihydrogenphosphate
• ATP
• PET quenching

We have developed a new ratiometric fluorescent chemosensor 1 based on xanthine alkaloid theophylline moiety for the detection of dihydrogen phosphate and ATP. The chemosensor 1 selectively recognizes tetrabutylammonium dihydrogen phosphate in CH3CN/H2O (9:1) by exhibiting a significant decrease in the emission of naphthalene and its sensing properties regarding ATP and other related phosphate species were evaluated. The anion binding properties of 1 were evaluated by H-1 NMR, UV-vis, and fluorescence spectroscopic methods.

• 出版日期2012-2-1