Bone bonding ability of a chemically and thermally treated low elastic modulus Ti alloy: gum metal

作者：Tanaka Masashi^*; Takemoto Mitsuru; Fujibayashi Shunsuke; Kawai Toshiyuki; Yamaguchi Seiji; Kizuki Takashi; Matsushita Tomiharu; Kokubo Tadashi; Nakamura Takashi; Matsuda Shuichi

来源：Journal of Materials Science: Materials in Medicine , 2014, 25(3): 635-643.

DOI：10.1007/s10856-013-5101-4

The gum metal with composition Ti-36Nb-2Ta-3Zr-0.3O, is free from cytotoxic elements and exhibits a low elastic modulus as well as high mechanical strength. We have previously demonstrated that this gum metal, once subjected to a series of surface treatments-immersion in 1 M NaOH (alkali treatment) and then 100 mM CaCl2, before heating at 700 A degrees C (sample: ACaH-GM), with an optional final hot water immersion (sample: ACaHW-GM)-has apatite-forming ability in simulated body fluid. To confirm the in vivo bioactivity of these treated alloys, failure loads between implants and bone at 4, 8, 16, and 26 weeks after implantation in rabbits' tibiae were measured for untreated gum metal (UT-GM), ACaH-GM and ACaHW-GM, as well as pure titanium plates after alkali and heat treatment (AH-Ti). The ACaH-GM and UT-GM plates showed almost no bonding, whereas ACaHW-GM and AH-Ti plates showed successful bonding by 4 weeks, and their failure loads subsequently increased with time. The histological findings showed a large amount of new bone in contact with the surface of ACaHW-GM and AH-Ti plates, suggesting that the ACaHW treatment could impart bone-bonding bioactivity to a gum metal in vivo. Thus, with this improved bioactive treatment, these advantageous gum metals become useful candidates for orthopedic and dental devices.

• 出版日期2014-3