Melicodenines A and B, novel Diels-Alder type adducts isolated from Melicope denhamii

作者:Nakashima Ken ichi; Oyama Masayoshi*; Ito Tetsuro; Witono Joko Ridho; Darnaedi Dedy; Tanaka Toshiyuki; Murata Jin; Iinuma Munekazu
来源:Tetrahedron Letters, 2011, 52(36): 4694-4696.
DOI:10.1016/j.tetlet.2011.07.013

摘要

Two novel Diels-Alder type adducts, melicodenines A (1) and B (2), were isolated from the leaves of Melicope denhamii (Seem.) T. G. Hartley and their structures were established by spectroscopic analyses, including extensive 2D NMR experiments. Compound 1 is a bisquinolinone alkaloid comprised of two N-methylflindersines (3), while compound 2 is the first naturally occurring quinolinone-acetophenone conjugate composed of 3 and an evodionol methyl ether (4).

  • 出版日期2011-9-7