Design of Oriented Porous PHBV Scaffold as a Neural Guide

作者：Biazar Esmaeil^*; Keshel Saeed Heidari; Sahebalzamani Ali; Heidari Majid

来源：International Journal of Polymeric Materials and Polymeric Biomaterials, 2014, 63(15): 753-757.

DOI：10.1080/00914037.2013.879446

• Cell investigations
• micro patterning
• neural guide
• oriented porous guide
• PHBV
• plasma modification

The aim of this study was to produce an oriented biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nerve guide. Oriented porous micropatterned artificial nerve guide designed onto the micro-patterned silicon wafers, then their surfaces modified with to oxygen plasma for cell attachment increasing. Afterwards, the neural guides were evaluated by microscopic, structural, physical, and mechanical analyses, and cell culture assays with Schwann cells. Results of structural, physical, and mechanical analyses showed a good resilience and compliance with movement as a neural graft. Cellular experiments showed a better cell adhesion, growth, and proliferation inside the plasma-modified neural guides compared to un-modified ones, also Schwann cells were well attached on plasma-modified surface. This neural guide appears to have the right organization for testing in vivo nerve tissue engineering studies.

• 出版日期2014