Stability indicating method for sodium montelukast in pharmaceutical preparations by micellar electrokinetic capillary chromatography

作者：Roman J^*; Malesuik M D; Jablonski A; Steppe M

来源：Pharmazie, 2010, 65(9): 645-649.

DOI：10.1691/ph.2010.0055

A simple, reliable micellar electrokinetic chromatography method (MEKC) for the determination of sodium montelukast in coated tablets was developed and validated. Successful results were obtained with 10 nnmol L(-1) borate buffer and 30 mmol L(-1) sodium dodecyl sulfate at pH 9.4, injection time of 5.0 s, an applied voltage of 25 kV and a column temperature of 25 degrees C. The detector response for sodium montelukast was linear over the concentration range from 20 to 100 mu g mL(-1) (r = 0.9995). The intra and inter-day precision showed suitable results (RSD < 1.46%). The analytical method accuracy was 99.67% (RSD = 1.11%). The limits of detection and quantitation were 0.75 and 2.00 mu g mL(-1) respectively. The method demonstrated robustness and showed to be viable for the sodium montelukast determination in pharmaceutical dosage form.

• 出版日期2010-9