A one-pot, reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids

作者：Fowler Lindsay S; Thomas Lynne H; Ellis David; Sutherland Andrew^*

来源：Chemical communications, 2011, 47(23): 6569-6571.

DOI：10.1039/c1cc11916h

The first stereoselective synthesis of 2,6-trans-6-substituted-4-oxo-L-pipecolic acids using a tandem reductive amination/6-endo-trig cyclisation process is described. The sequential reduction and cyclisation mediated by sodium cyanoborohydride allowed the preparation of a series of highly functionalised 6-alkyl and 6-aryl analogues.

• 出版日期2011