Mouse Models of Myelodysplastic Syndromes

作者：Beachy Sarah H; Aplan Peter D^*

来源：Hematology-Oncology Clinics of North America, 2010, 24(2): 361-+.

DOI：10.1016/j.hoc.2010.02.002

• Myelodysplastic syndrome
• Mouse model
• Xenotransplant
• Genetically engineered mice
• Hoxa

Three general approaches have been used to model myelodysplastic syndrome (MDS) in mice, including treatment with mutagens or carcinogens, xenotransplantation of human MDS cells, and genetic engineering of mouse hematopoietic cells. This article discusses the phenotypes observed in available mouse models for MDS with a concentration on a model that leads to aberrant expression of conserved homeobox genes that are important regulators of normal hematopoiesis. Using these models of MDS should allow a more complete understanding of the disease process and provide a platform for preclinical testing of therapeutic approaches.

• 出版日期2010-4