摘要
We report the emergence of VIM-1 MBL and CDC-M-15-producing K pneumoniae isolates collected from patients at two acute care hospitals (I.R.C.C.S. %26quot;S. Matteo%26quot; and %26quot;Casa Sollievo della Sofferenza%26quot; Hospital) and a long-term rehabilitation facility in Northern Italy (I.R.C.C.S. %26quot;S. Maugeri%26quot;). %26lt;br%26gt;Between February 2007 and October 2008, 30 K pneumoniae strains showing decreased susceptibility to carbapenems were collected. PCR and sequencing experiments revealed the presence of bla(VIM-1) gene in 14/30 isolates. All the above isolates carried the bla(SHV-5) determinant as well; interestingly, 8/14 VIM positive isolates were also CDC-M-1-like producers. VIM-1 positive strains were present in all hospitals. PFGE genomic profiles of the 14/30 isolates showed that 2 different clones, A and B, were responsible for outbreaks. %26lt;br%26gt;The coexistence in the same bacterial cell of compatible plasmids carrying epidemiologically important emerging resistance genes, such as MBLs and CTX-Ms, is worrisome since it could predict the generation and spread of pan-resistant bacteria and the consequent treatment option limitations that can lead to significant morbidity and mortality. Control measures should be applied to detect MBL-producing strains and to contrast the vertical and plasmidic diffusion of carbapenem-resistant K pneumoniae in acute care and rehabilitation facilities.
- 出版日期2013-7