Agr function is upregulated by photodynamic therapy for Staphylococcus aureus and is related to resistance to photodynamic therapy

作者：Park Hee Jeong; Moon Yeon Hee; Yoon Hyo Eun; Park Yoon Mee; Yoon Jung Hoon; Bang Iel Soo^*

来源：Microbiology and Immunology, 2013, 57(8): 547-552.

DOI：10.1111/1348-0421.12070

• accessory gene regulator
• antimicrobial therapy
• multidrug resistance
• photodynamic therapy

Photodynamic therapy (PDT) has been considered a feasible alternative for antimicrobial therapy of multidrug-resistant pathogens. However, bacterial response mechanisms against PDT-generated photo-oxidative stress remain largely unknown. Herein, it is shown that the accessory gene regulator Agr is involved in Staphylococcus aureus response to photo-oxidative stress generated by laser-induced PDT with the photosensitizer chlorin e(6). Transcriptional profiling revealed that sublethal PDT induces a general stress response and also activates Agr-dependent gene regulation. Moreover, mutant S. aureus lacking Agr function showed hypersusceptibility to two independent PDT conditions with higher energy densities, demonstrating Agr-dependent S. aureus resistance against PDT.

• 出版日期2013-8