Nuclear Pregnane X Receptor Single Nucleotide Polymorphism (-25385C/T) Is Not Associated With Inflammatory Bowel Disease in Pediatric Patients

作者：Lacher Martin^*; Kappler Roland; Schroepf Sebastian; Berkholz Stefan; Ballauff Antje; Bufler Philip; Baurecht Hansjoerg; von Schweinitz Dietrich; Koletzko Sibylle

来源：Journal of Pediatric Gastroenterology and Nutrition, 2009, 49(1): 147-150.

DOI：10.1097/mpg.0b013e31818de1a8

• Crohn disease
• Inflammatory bowel disease
• NR112
• PXR
• Ulcerative colitis

Objective: Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking.
Patients and Methods: Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and 185 controls. Determination of colonic PXR expression in selected patients with IBD.
Results: Minor allele frequency was seen in 35.6% patients with MID and 40.5% controls (P=0.174), although 110 significant differences were seen between the genotypes (P=0.366). PXR was underexpressed in colonic tissue of 7 out of 11 Crohn disease and in 4 Out of 5 patients with ulcerative colitis.
Conclusions: We could not confirm an association of the -25385C/T polymorphism in pediatric patients with IBD. JPGN 49:147-150, 2009.

• 出版日期2009-7
• 单位河北医科大学