A Case of Membranous Nephropathy with Primary Biliary Cirrhosis and Cyclosporine-induced Remission

作者：Sakamaki Yusuke^*; Hayashi Matsuhiko; Wakino Shu; Fukuda Seiichi; Konishi Kounosuke; Hashiguchi Akinori; Hayashi Koichi; Itoh Hiroshi

来源：Internal Medicine, 2011, 50(3): 233-238.

DOI：10.2169/internalmedicine.50.4020

• membranous nephropathy
• primary biliary cirrhosis
• nephrotic syndrome
• cyclosporine

We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral (R)), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.

• 出版日期2011