Activation of dioxygen by copper metalloproteins and insights from model complexes

作者：Quist David A; Diaz Daniel E; Liu Jeffrey J; Karlin Kenneth D

来源：Journal of Biological Inorganic Chemistry, 2017, 22(2-3): 253-288.

DOI：10.1007/s00775-016-1415-2

• Copper
• Dioxygen activation
• Copper enzymes
• Enzymatic mechanisms
• Cofactor biogenesis

Nature uses dioxygen as a key oxidant in the transformation of biomolecules. Among the enzymes that are utilized for these reactions are copper-containing metalloenzymes, which are responsible for important biological functions such as the regulation of neurotransmitters, dioxygen transport, and cellular respiration. Enzymatic and model system studies work in tandem in order to gain an understanding of the fundamental reductive activation of dioxygen by copper complexes. This review covers the most recent advancements in the structures, spectroscopy, and reaction mechanisms for dioxygen-activating copper proteins and relevant synthetic models thereof. An emphasis has also been placed on cofactor biogenesis, a fundamentally important process whereby biomolecules are post-translationally modified by the pro-enzyme active site to generate cofactors which are essential for the catalytic enzymatic reaction. Significant questions remaining in copper-ion-mediated O-2-activation in copper proteins are addressed.

• 出版日期2017-4