Antimullerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

作者：White Alexandra J^*; Sandler Dale P; D'Aloisio Aimee A; Stanczyk Frank; Whitworth Kristina W; Baird Donna D; Nichols Hazel B

来源：Fertility and Sterility, 2016, 106(3): 723-730.

DOI：10.1016/j.fertnstert.2016.05.015

• Tobacco
• environmental tobacco smoke
• Anti-Mullerian Hormone
• breast cancer
• indoor air pollution

Objective: To evaluate exposure to tobacco, marijuana, and indoor heating/cooking sources in relation to antimullerian hormone (AMH) levels.
Design: Cross-sectional analysis in a sample of premenopausal women (n = 913) enrolled in the Sister Study cohort (n = 50,884).
Setting: Not applicable.
Patient(s): Women, ages 35-54 years at time of enrollment, with an archived serum sample and at least one intact ovary and classified as premenopausal.
Intervention(s): Not applicable.
Main Outcome Measure(s): Serum AMH (ng/mL) levels ascertained by ultrasensitive ELISA assay.
Result(s): Lower AMH levels were associated with sources of indoor heating, including burning wood (-36.0%; 95% confidence interval [CI], -55.7%, -7.8%) or artificial fire logs (-45.8%; 95% CI, -67.2%, -10.4%) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of >= 20 cigarettes/day relative to nonsmokers (-56.2%; 95% CI, -80.3%, -2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (-31.3%; 95% CI, -51.3%, -3.1%), but no associations were observed for marijuana use.
Conclusion(s): We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial fire logs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary.

• 出版日期2016-9-1