Duration of Obesity and Overweight and Risk of Type 2 Diabetes Among US Women

作者：Hu Yang; Bhupathiraju Shilpa N; de Koning Lawrence; Hu Frank B^*

来源：Obesity, 2014, 22(10): 2267-2273.

DOI：10.1002/oby.20851

ObjectiveThe purpose of this study was to examine the association between duration of adiposity and risk of type 2 diabetes (T2D) in US women. %26lt;br%26gt;MethodsNearly 61,821 participants were prospectively followed from the Nurses%26apos; Health Study (1984-2008) and 63,653 participants from Nurses%26apos; Health Study II (1991-2011). Participants were considered overweight (BMI 25-30 kg m(-2)) or obese (BMI30 kg m(-2)) if their BMI was above the cutoffs for two successive assessments. The time-dependent Cox proportional hazard models were used to assess associations between excess weight duration and T2D risk. %26lt;br%26gt;ResultsIn pooled multivariable analyses of the two cohorts, each two extra years of being overweight was associated with 9% (RR=1.09, 95% CI 1.08-1.09) increased risk of developing T2D. For each 2-year increment in obesity duration, the risk of T2D was increased by 14% (RR=1.14, 95% CI 1.14-1.15). Adjustment for current BMI greatly attenuated the association for obesity duration (RR=1.02, 95% CI 1.01-1.03), although the attenuation was less for overweight duration (RR=1.04, 95% CI 1.04-1.05). %26lt;br%26gt;ConclusionsBoth overweight and obesity duration were associated with a significantly higher risk of T2D, and these associations were mainly explained by current BMI, especially for obesity duration.

• 出版日期2014-10