An effective conversion of N '-ethoxymethylene-2-(N-Boc-amino)propionohydrazides into 2-(1-aminoethyl)-1,3,4-oxadiazoles

作者：Kudelko Agnieszka^*; Zielinski Wojciech

来源：ARKIVOC, 2009, 1-8.

• N '-Ethoxymethylene-2-(N-Boc-amino)propionohydrazide
• 1,3,4-oxadiazole
• cyclization
• syn and anti isomerism
• Boc protecting group

A series of N'-ethoxymethylene-2-(N-Boc-amino)propionohydrazide derivatives was obtained from the reactions of N-Boc-protected alanine hydrazide and triethyl orthoesters. They underwent cyclization to the corresponding 2-(1-N-Boc-aminoethyl)-1,3,4-oxadiazoles in glacial acetic acid.

• 出版日期2009