A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

作者：Mazein Alexander; Watterson Steven; Hsieh Wei Yuan; Griffiths William J; Ghazal Peter^*

来源：Biochemical Pharmacology, 2013, 86(1): 56-66.

DOI：10.1016/j.bcp.2013.03.021

• Cholesterol
• Sterol
• SBGN
• Metabolic network
• Pathway map

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

• 出版日期2013-7-1