Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker

作者：Venkatesh Pichairajan; Mukherjee Pulok K^*; Kumar Nanjappan Satheesh; Bandyopadhyay Arun; Fukui Hiroyuki; Mizuguchi Hiroyuki; Islam Nurul

来源：Immunopharmacology and Immunotoxicology, 2010, 32(2): 272-276.

DOI：10.3109/08923970903305481

Material and methods: The percentage of catechin in the ethanolic extract was found to be 14.72 mg/g. We administered Albizia lebbeck (50-300 mg/kg) and 50 mg/kg of catechin to mice to evaluate the mast cell stabilization and estimation of histamine elevation in the plasma.
Results and conclusion: Results support the conclusion that Albizia lebbeck at different concentrations has got potent mast cell stabilizing property and the IC50 value of Albizia lebbeck was found to be 85 mu g/ml. This inhibitory potential of catechin from Albizia lebbeck is perhaps due to modulation of two important effector's functions, histamine release and cytokine expression of antigen -IgE activated mast cells.

• 出版日期2010-6