A facile and expeditious approach for the synthesis of 2-azetidinone derivatives via a multicomponent reaction

作者：Keri Rangappa S; Hosamani Kallappa M^*

来源：Monatshefte fur Chemie, 2010, 141(8): 883-888.

DOI：10.1007/s00706-010-0342-0

• Multicomponent reaction
• One-pot synthesis
• Coumarin
• 2-Azetidinones

New organic reactions allow chemical transformations which were previously unknown. Therefore, new reactions are important contributions to progress in the field of organic synthesis. Herein, we are reporting a simple, one-pot, efficient three-component synthesis of novel 3-chloro-4-[4-(2-oxo-2H-chromen-4-ylmethoxy)phenyl]-1-phenylazetidin-2-one derivatives using 4-(2-oxo-2H-chromen-4-ylmethoxy)benzaldehydes, anilines, and chloroacetyl chloride in the presence of triethyl amine as a catalyst under different conditions. Taking into account environmental and economic considerations, the protocol presented here has the merits of simple operation, convenient work-up, being environmentally benign, and providing good yields. The synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, MS, and elemental analysis.

• 出版日期2010-8