Advances in radionuclide imaging of cardiac sarcoidosis

作者：Kouranos V; Wells A U; Sharma R; Underwood S R; Wechalekar K^*

来源：British Medical Bulletin, 2015, 115(1): 151-163.

DOI：10.1093/bmb/ldv033

• cardiac sarcoidosis
• radionuclide imaging
• FDG-PET
• SPECT

Introduction: Radionuclide imaging for the diagnosis and monitoring of cardiac involvement in sarcoidosis has advanced significantly in recent years.
Sources of data: This article is based on published clinical guidelines, literature review and our collective clinical experience.
Areas of agreement: Gallium-67 scintigraphy is among the diagnostic criteria for cardiac involvement in systemic sarcoidosis, and it is strongly associated with response to treatment. However, fluorine-18, 2-fluoro-deoxyglucose (FDG) positron emission tomography (PET) is now preferred both for diagnosis and for assessing prognosis.
Areas of controversy: Most data are from small observational studies that are potentially biased.
Growing points: Quantitative imaging to assess changes in disease activity in response to treatment may lead to FDG-PET having an important routine role in managing cardiac sarcoidosis.
Areas timely for developing research: Larger prospective studies are required, particularly to assess the effectiveness of radionuclide imaging in improving clinical management and outcome.

• 出版日期2015-9