ANCA-associated vasculitides: Pathogenetic aspects and current evidence-based therapy

作者：Holle J U^*; Gross W L

来源：Journal of Autoimmunity, 2009, 32(3-4): 163-171.

DOI：10.1016/j.jaut.2009.02.019

• ANCA-associated vasculitis
• Wegener's granulomatosis
• Evidence-based therapy
• EULAR recommendations

A lot of progress has been made regarding the therapy of ANCA-associated vasculitides in the past decades. Cyclophosphamide still is standard therapy for remission induction in generalized disease, however, duration and cumulative dose of cyclophosphamide have been curtailed successfully to reduce toxicity. MTX is a safe alternative for remission induction in early systemic disease and medications available for remission maintenance have been extended. Rituximab and TNFalpha-antagonists represent promising options for refractory disease. The current evidence of therapy of ANCA-associated vasculitides is summarized in this review.

• 出版日期2009-6