Anti-adenovirus humoral responses influence on the efficacy of vaccines based on epitope display on adenovirus capsid

作者：Lanzi Anastasia; Ben Youssef Ghada; Perricaudet Michel; Benihoud Karim^*

来源：Vaccine, 2011, 29(7): 1463-1471.

DOI：10.1016/j.vaccine.2010.12.025

• Adenovirus
• Capsid
• Epitope

The efficacy of recombinant adenoviruses (Ads) vaccine vectors is diminished by the high prevalence of anti-Ad antibodies (Abs) that hampers gene transfer. Epitope display on Ad capsid constitutes an alternative approach to bypass anti-Ad Ab capacity from blocking antigen expression. To understand the role of the epitope insertion site, an ovalbumin-derived epitope was genetically inserted into either Ad hexon or fiber proteins. Hexon-modified Ads triggered higher anti-ovalbumin Ab responses after one injection but surprisingly fiber-modified Ads were by far more potent after two or several administrations. Our data unravel a role for anti-Ad humoral immunity in controlling anti-epitope humoral responses.

• 出版日期2011-2-4