A novel and efficient one-pot four-component tandem approach for the synthesis of pyran derivatives

作者：Zhang, Zhanyi; Xu, Yijing; Zheng, Jia; Li, Bin; Li, Yiqun^*

来源：Molecular Diversity, 2012, 16(3): 423-430.

DOI：10.1007/s11030-012-9375-0

• Pyran derivatives
• Four-component reaction
• Tandem reaction
• Pd/C

A series of new pyran derivatives are efficiently synthesized in a one-pot four-component tandem reaction via Suzuki coupling followed by a three-component reaction from readily available 4-bromobenzaldehyde, activated methylene compounds, and carbonyl compounds. Single crystal X-ray structure of the synthesized product is presented. The versatility and efficiency of the proposed methodology has been demonstrated in the synthesis of novel heterocyclic molecules.

• 单位
  暨南大学