A convenient synthesis of Lupeol from Betulin

作者：Liu, Suyou^*; Xu, Fei; Liu, Lijun; Ma, Dayou

来源：Industrial Crops and Products, 2015, 74: 494-496.

DOI：10.1016/j.indcrop.2015.05.071

• Betulin
• Lupeol
• Semi-synthesis
• Wolff-Kishner reaction

Lupeol is an immense bioactive lupane-type triterpenoid that can be isolated from several different medicinal plants but in low yields. While, betulin, a triterpenoid structurally shares great similarities to lupeol, is present in concentrations as high as 30% of the dried bark of white birch, accounts for up to 78% content of the birch bark extractive. In this study a convenient synthesis of lupeol from betulin was successfully established with an overall yield of 50% in 4 steps. On the basis of this study, betulin from white birch species can be used as an economic and ever available source for lupeol.

• 出版日期2015-11-15
• 单位中南大学