Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of A beta(25-35)-Induced Axonal Atrophy

作者：Yang Zhi You; Kuboyama Tomoharu; Kazuma Kohei; Konno Katsuhiro; Tohda Chihiro^*

来源：Journal of Natural Products, 2015, 78(9): 2297-2300.

DOI：10.1021/acs.jnatprod.5b00290

Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimer's,disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract of Drynaria fortunei rhizomes reversed A beta(25-35)-induced axonal atrophy in cultured cortical neurons of mice. Bioassay-guided fractionation of this extract led to the isolation and identification of compounds 1-5. Among them, (2S)-neoeriocitrin (2) and caffeic acid 4-O-glucoside (4) showed significant axonal elongation effects on A beta(25-35)-induced atrophy.

• 出版日期2015-9