Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior

作者：Barker Jacqueline M; Torregrossa Mary M; Taylor Jane R^*

来源：Nature Neuroscience, 2012, 15(10): 1356-1358.

DOI：10.1038/nn.3194

The factors underlying vulnerability to alcoholism are largely unknown. We identified in rodents an innate endophenotype predicting individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related polysialylated neural cell adhesion molecule (PSA-NCAM). Depletion of PSA-NCAM in the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. These data suggest a mechanism of aberrant prefrontal neuroplasticity that underlies enhanced propensity for inflexible addiction-related behavior.

• 出版日期2012-10
• 单位上海市精神卫生中心