Association of HLA-DQB1 polymorphisms with rheumatoid arthritis: a meta-analysis

作者：Wu, Jun; Li, Jun; Li, Si; Zhang, Tian-Ping; Li, Lian-Ju; Lv, Tian-Tian; Pan, Hai-Feng^*; Ye, Dong-Qing^*

来源：Postgraduate Medical Journal, 2017, 93(1104): 618-625.

DOI：10.1136/postgradmedj-2016-134724

• SYSTEMIC-LUPUS-ERYTHEMATOSUS
• LATIN-AMERICAN PATIENTS
• HLA POLYMORPHISM
• HLA-DRB1
• ALLELES
• SUSCEPTIBILITY
• POPULATION
• DQ
• PTPN22
• GENE

Aim Studies investigating the association between HLA-DQB1 alleles and rheumatoid arthritis (RA) have reported conflicting results. The purpose of this study was to evaluate whether DQB1 alleles confer susceptibility to RA.
Design A comprehensive literature search up to May 2016 was conducted to identify case-control studies on the association of HLA-DQB1 alleles with RA. Pooled ORs with 95% CIs were used to assess the strength of association.
Setting The literature indicates that HLA-DQB1 is associated with susceptibility to RA.
Main outcome measures Frequencies of HLA-DQB1 alleles and phenotype in RA patients and healthy controls.
Results Fifteen studies with 1250 cases and 1621 controls were included in this meta-analysis. DQB1 alleles were associated with RA susceptibility. The frequencies of DQB1*06 were lower in RA (p-value for comparability=0.007, OR 0.726,95% CI 0.576 to 0.916; p=0.004, OR 0.611,95% CI 0.438 to 0.852). The frequencies of DQB1* 02 were lower in RA (p=0.044, OR 0.731,95% CI 0.597 to 0.895). A higher frequency of DQB1*04 was observed in RA (p=0.023, OR 1.604,95% CI 1.067 to 2.410).
Conclusions This meta-analysis demonstrates that DQB1*02 and DQB1*06 may be negatively associated with RA. Conversely, DQB1*04 may confer susceptibility to RA.

• 出版日期2017-10
• 单位安徽医科大学