Borylation and selective reduction of α,β-unsaturated ketones under mild conditions catalyzed by Cu nanoparticles

作者：Zhou, Xin-Feng; Sun, Yu Yang; Wu, Ya-Dong; Dai, Jian-Jun; Xu, Jun; Huang, Yu^*; Xu, Hua-Jian^*

来源：Tetrahedron, 2016, 72(37): 5691-5698.

DOI：10.1016/j.tet.2016.07.079

• Cu nanoparticles
• Borylation
• alpha,beta-unsaturated ketones
• Protodeboration

An effective strategy for synthesis of Cu nanoparticles is designed, these nanoparticles have high catalytic activity in conjugate addition of B-2(pin)(2) and alpha,beta-unsaturated ketones. The reaction of protodeboration can proceed with adding NaOtBu. In this way, a new method to reduce the conjugated alkenes of alpha,beta-unsaturated ketones is developed with organoboranes as intermediates. Cu nanocrystals also have excellent performance in gram-scale reaction and recycling experiment. A possible mechanism is proposed.

• 出版日期2016-9-15
• 单位合肥工业大学