Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future

作者：Ferir Geoffrey; Kaptein Suzanne; Neyts Johan^*; De Clercq Erik

来源：Reviews in Medical Virology, 2008, 18(1): 19-34.

DOI：10.1002/rmv.554

A decade ago, standard therapy against chronic hepatitis B virus infections only consisted of lamivudine or IFN-alpha. Treatment with lamivudine and IFN has been compounded by, respectively, the emergence of drug-resistant virus strains and the appearance of serious side effects. In the last 10 years, hepatitis B treatment has made much progress. Several treatments are now licensed for the treatment of patients with chronic hepatitis B and others are under development. Here, we provide an overview of the potential and mode of action of anti-HBV agents that are currently available, and/or may become available in the near future. Foremost among these newer compounds are adefovir dipivoxil, entecavir and telbivudine.

• 出版日期2008-2