A comparison of early diagnostic utility of Alzheimer disease biomarkers in brain magnetic resonance and cerebrospinal fluid

作者：Monge Argiles J A; Blanco Canto M A; Leiva Salinas C; Flors L; Munoz Ruiz C; Sanchez Paya J; Gasparini Berenguer R; Leiva Santana C

来源：Neurologia, 2014, 29(7): 397-401.

DOI：10.1016/j.nrl.2013.06.002

• Biomarkers
• Mild cognitive impairment
• Early diagnosis
• Alzheimer disease
• Cerebrospinal fluid
• Brain magnetic resonance

Introduction: The goals of this study were to compare the early diagnostic utility of Alzheimer disease biomarkers in the CSF with those in brain MRI in conditions found in our clinical practice, and to ascertain the diagnostic accuracy of both techniques used together. %26lt;br%26gt;Methods: Between 2008 and 2009, we included 30 patients with mild cognitive impairment (MCI) who were examined using 1.5 Testa brain MRI and AD biomarker analysis in CSF. MRI studies were evaluated by 2 radiologists according to the Korf%26apos;s visual scale. CSF biomarkers were analysed using INNOTEST reagents for A beta(1-42), total-tau and phospho-tau(181p). We evaluated clinical changes 2 years after inclusion. %26lt;br%26gt;Results: By 2 years after inclusion, 15 of the original 30 patients (50%) had developed AD (NINCDS-ADRA criteria). The predictive utility of AD biomarkers in CSF (RR 2.7; 95% CI, 1.1-6.7; P%26lt;.01) was greater than that of MRI (RR 1.5; 95% CI 95%, 0.7-3.4; P%26lt;.2); using both techniques together yielded a sensitivity and a negative predictive value of 100%. Normal results on both complementary tests ruled out progression to AD (100%) within 2 years of inclusion. %26lt;br%26gt;Conclusions: Our results show that the diagnostic accuracy of biomarkers in CSF is higher than that of biomarkers in MRI. Combined use of both techniques is highly accurate for either early diagnosis or exclusion of AD in patients with MCI.

• 出版日期2014-9