New sequence variants associated with bone mineral density

作者：Styrkarsdottir Unnur; Halldorsson Bjarni V; Gretarsdottir Solveig; Gudbjartsson Daniel F; Walters G Bragi; Ingvarsson Thorvaldur; Jonsdottir Thorbjorg; Saemundsdottir Jona; Snorradottir Steinunn; Center Jacqueline R; Nguyen Tuan V; Alexandersen Peter; Gulcher Jeffrey R; Eisman John A; Christiansen Claus; Sigurdsson Gunnar; Kong Augustine; Thorsteinsdottir Unnur; Stefansson Kari^*

来源：Nature Genetics, 2009, 41(1): 15-17.

DOI：10.1038/ng.284

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

• 出版日期2009-1
• 单位河北医科大学