A neural network for predicting the stability of DNA/DNA duplexes

作者：Liu XH; Ma LX; Cheng CM^*; Wang Y; Miyajima H; Zhao YF

来源：Nucleosides Nucleotides & Nucleic Acids, 2005, 24(3): 199-209.

DOI：10.1081/NCN-200055718

• melting temperature
• DNA duplex
• neural network

A back-propagation neural network method has been developed to predict the stability of DNA/DNA duplexes. Calculated T. with the present Parameters fits the experimental values within reasonable errors (AD = 1.86 K, SEP = 1.9915 7, R2 = 0.9894 for NN1; AD = 1.59667 K, SEP = 2.03824, R2 = 0.99371 for NN2), and it has the advantage that the determinations of thermodynamic parameters are not needed.

• 出版日期2005
• 单位清华大学; 上海电力大学