Associations of lipid profiles with insulin resistance and beta cell function in adults with normal glucose tolerance and different categories of impaired glucose regulation

作者：Zheng, Shuang; Xu, Hua; Zhou, Huan; Ren, Xingxing; Han, Tingting; Chen, Yawen; Qiu, Huiying; Wu, Peihong; Zheng, Jun; Wang, Lihua; Liu, Wei^*; Hu, Yaomin^*

来源：PLos One, 2017, 12(2): e0172221.

DOI：10.1371/journal.pone.0172221

• TYPE-2 DIABETES-MELLITUS
• CARDIOVASCULAR RISK
• FASTING GLUCOSE
• NITRIC-OXIDE
• SECRETION
• CHOLESTEROL
• SENSITIVITY
• INDIVIDUALS
• DYSFUNCTION
• PREVALENCE

Aims
To investigate the associations of dyslipidemia with insulin resistance and beta cell function in individuals with normal glucose tolerance (NGT) and different categories of impaired glucose regulation (IGR).
Methods
544 subjects (365 with dyslipidemia and/or IGR and 179 with normal lipid and glucose tolerance) were enrolled in the study. All subjects underwent oral glucose tolerance test (OGTT). HOMA-IR was used to evaluate insulin sensitivity. Disposition index (DI) was used to evaluate beta cell function. Multiple linear regression analysis was performed to assess correlations among lipid profiles, insulin resistance and beta cell function.
Results
Among subjects with NGT, those with dyslipidemia had higher level of HOMA-IR but lower level of DI. While among subjects with different categories of IGR, those with dyslipidemia and CGI had significantly decreased DI. No obvious differences of insulin resistance or beta cell function were found in IFG or IGT subjects with or without dyslipidemia. TG and HDL-C were correlated with HOMA-IR (beta = 0.79, p < 0.001; beta = -0.38, p = 0.027, respectively, compared with subjects in the low level groups). Moreover, TG and TC were negatively correlated with DI (beta = -2.17, p = 0.013; beta = -2.01, p = 0.034 respectively, compared with subjects in the low level groups) after adjusting for confounding parameters.
Conclusions
Dyslipidemia induces insulin resistance and impaired beta cell response to insulin resistance in individuals with NGT. Furthermore, dyslipidemia diminishes beta cell function in subjects with CGI. TG and HDL-C were correlated with insulin resistance, and TG, TC were negatively correlated with beta cell response to insulin resistance in non-diabetic individuals.

• 出版日期2017-2-15
• 单位上海交通大学