Activity determination and nuclear decay data of Lu-177

作者：Kossert Karsten^*; Naehle Ole J; Ott Oliver; Dersch Rainer

来源：Applied Radiation and Isotopes, 2012, 70(9): 2215-2221.

DOI：10.1016/j.apradiso.2012.02.104

• Lu-177
• Activity standardization
• Photon emission probabilities
• Half-life

The activity concentration of a Lu-177 solution was measured within the scope of the international comparison CCRI(II)-K2.Lu-177, starting in 2009. At PTB, the solution was measured by means of 4 pi beta-gamma coincidence counting using a proportional counter and a Nal detector. In addition, liquid scintillation counting using the CIEMAT/NIST efficiency tracing method as well as the triple-to-double coincidence ratio (TDCR) method was applied. The efficiency computation for the TDCR method was realized by means of the MICELLE2 program, applying a stochastic model for the computation of electron emission spectra.
The activity concentrations derived from the three methods were found to be in good agreement and the relative standard uncertainty of the combined result was found to be 0.19%.
At PTB, the combined result was used to calibrate a 4 pi ionization chamber for future calibrations of this isotope which is frequently used in nuclear medicine.
In addition, activity standardizations were combined with gamma-ray spectrometry to determine photon emission probabilities. To this end, the comparison solution as well as another Lu-177 solution was used. The results are in good agreement with previous measurements at PTB but show a considerable discrepancy to recently published values from Deepa et al. (2011).
The decay curve of a third solution was followed by liquid scintillation counting for about 66 days to determine the half-life of Lu-177, which was found to be T-1/2=6.639(9) d.

• 出版日期2012-9