A new C-20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

作者：Chen, Lin; Shan, Lianhai; Xu, Wenliang; Zhang, Jifa; Huang, Shuai^*; Zhou, Xianli^*

来源：Natural Product Research, 2017, 31(5): 523-528.

DOI：10.1080/14786419.2016.1198348

• Diterpenoid alkaloid
• pubesine
• Aconitum soongaricum var. pubescens
• cytotoxic activity

A new denudatine-type C-20-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.

• 出版日期2017
• 单位西南交通大学; 西华师范大学