Atorvastatin attenuates NF-kappa B activation in trigeminal nucleus caudalis in a rat model of migraine

作者：Yin, Zhao^*; Fang, Yannan; Ren, Li; Wang, Xiaojuan; Zhang, Aiwu; Lin, Jianwen; Li, Xianliang

来源：Neuroscience Letters, 2009, 465(1): 61-65.

DOI：10.1016/j.neulet.2009.08.081

• Atorvastatin
• NF-kappa B
• Trigeminal nucleus caudalis (TNC)
• Nitroglycerin (NTG)
• Migraine

Nitroglycerin-induced NF-kappa B activation in trigeminal nucleus caudalis is believed to be partly involved in the pathogenesis of migraine. Atorvastatin, an inhibitor of HMG-CoA reductase, is thought to have pleiotropic effects in various neurologic diseases. Moreover, there are several lines of evidences that atorvastatin inhibits NF-KB activation in peripheral blood mononuclear cells. Thus, this study aims to explore whether atorvastatin attenuates NF-KB activation in trigeminal nucleus caudalis in a nitroglycerin-induced migraine model. A significant increase in nuclear content of 65, an indicator of NF-KB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin. However, the nitroglycerin-induced NF-KB activation in trigeminal nucleus caudalis was attenuated by pretreatment with atorvastatin in a dose-dependent fashion. These results suggest that atorvastatin may be a novel and promising candidate for future treatment or prophylaxis of migraine via attenuating activation of NF-KB in trigeminal nucleus caudalis.

• 出版日期2009-11-6
• 单位中山大学