Bisphenol A in combination with TNF-α selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

作者：Guo, Hongchuan; Liu, Tianyi; Uemura, Yasushi^*; Jiao, Shunchang; Wang, Deqing; Lin, Zilin; Narita, Yayoi; Suzuki, Motoharu; Hirosawa, Narumi; Ichihara, Yasuko; Ishihara, Osamu; Kikuchi, Hirosato; Sakamoto, Yasushi; Senju, Satoru; Zhang, Qiuhang; Ling, Feng

来源：Cellular and Molecular Immunology, 2010, 7(3): 227-234.

DOI：10.1038/cmi.2010.14

• bisphenol A
• dendritic cells
• Th1/2
• human

Bisphenol A (BPA) is a monomer used in manufacturing a wide range of chemical products, including epoxy resins and polycarbonate. BPA, an important endocrine disrupting chemical that exerts estrogen-like activities, is detectable at nanomolar levels in human serum worldwide. The pregnancy associated doses of 17 beta-estradiol (E2) plus tumor-necrosis factor-alpha (TNF-alpha) induce distorted maturation of human dendritic cells (DCs) that result in an increased capacity to induce T helper (Th) 2 responses. The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs, thereby polarizing the subsequent Th response. In the presence of TNF-alpha, BPA treatment enhanced the expression of CC chemokine ligand 1 (CCL1) in DCs. In addition, DCs exposed to BPA/TNF-alpha produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation, and preferentially induced Th2 deviation. BPA exerts the same effect with E2 at the same dose (0.01-0.1 mu M) with regard to DC-mediated Th2 polarization. These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. Cellular & Molecular Immunology (2010) 7, 227-234; doi:10.1038/cmi.2010.14; published online 12 April 2010

• 出版日期2010-5
• 单位中国人民解放军总医院; 首都医科大学