Design and Structure Activity Correlation of RGDS Cell-Attachment Peptide Containing Molecules

作者：Hirano Yoshiaki^*; Inai Koji; Oka Masahito

来源：Kobunshi Ronbunshu, 2012, 69(1): 11-19.

DOI：10.1295/koron.69.11

• RGDS
• (RGDS)(n)
• Molecular Dynamics Calculations
• Conformational Analysis
• Cell-Attachment
• CD Spectrum
• L929 Fibroblast Cell
• Peptide-Polymer Conjugate

RGDS peptide is a widely known cell-attachment peptide. In the present publication, the molecular design of molecules that incorporate two or more RGDS peptides and their conjugates with water-soluble polymers is reported. The cell attachment activity of these peptides was examined out by cell inhibition experiments. RGDS and (RGDS)(n) peptides in aqueous solutions were analyzed by molecular dynamics calculations. We discuss the relationship between the theoretical structural analysis and experimental conformation analysis obtained by CD spectra. The theoretical structural analysis and the experimental structural analysis were well in agreement. Furthermore, we discuss the activity of cell attachment and structure of peptide, from the viewpoint of cell attachment biomaterials.

• 出版日期2012-1