Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

作者：Ergonul O^*; Aydin M; Azap A; Basaran S; Tekin S; Kaya S; Gulsun S; Yoruk G; Kursun E; Yesilkaya A; Simsek F; Yilmaz E; Bilgin H; Hatipoglu C; Cabadak H; Tezer Y; Togan T; Karaoglan I; Inan A; Engin A; Aliskan H E; Yavuz S S; Erdinc S; Mulazimoglu L; Azap O; Can F; Akalin H; Timurkaynak F

来源：Journal of Hospital Infection, 2016, 94(4): 381-385.

DOI：10.1016/j.jhin.2016.08.012

• Bloodstream
• Gram-negative
• Healthcare

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality.

• 出版日期2016-12