GenePRIMP: a gene prediction improvement pipeline for prokaryotic genomes

作者：Pati Amrita^*; Ivanova Natalia N; Mikhailova Natalia; Ovchinnikova Galina; Hooper Sean D; Lykidis Athanasios; Kyrpides Nikos C

来源：Nature Methods, 2010, 7(6): 455-U62.

DOI：10.1038/NMETH.1457

We present 'gene prediction improvement pipeline' (GenePRIMP; http://geneprimp.jgi-psf.org/), a computational process that performs evidence-based evaluation of gene models in prokaryotic genomes and reports anomalies including inconsistent start sites, missed genes and split genes. We found that manual curation of gene models using the anomaly reports generated by GenePRIMP improved their quality, and demonstrate the applicability of GenePRIMP in improving finishing quality and comparing different genome-sequencing and annotation technologies.

• 出版日期2010-6