Age-related changes in pre- and postmenopausal women investigated with F-18-fluoride PET-a preliminary study

作者：Kurata Seiji^*; Shizukuishi Kazuya; Tateishi Ukihide; Yoneyama Tomohiro; Hino Ayako; Ishibashi Masatoshi; Inoue Tomio

来源：Skeletal Radiology, 2012, 41(8): 947-953.

DOI：10.1007/s00256-011-1318-9

• PET
• F-18-fluoride
• Bone metabolism
• Advancing age
• Menopause

To evaluate the relationship between age and regional skeletal uptake at sites consisting of either predominantly trabecular or cortical bone using F-18-fluoride positron emission tomography (PET) in pre- and postmenopausal women. %26lt;br%26gt;Thirty-two women (40.6 +/- 12.3 years; age range 25-72 years) were assigned to one of two groups: group 1 comprised 22 premenopausal women (33 +/- 6.5 years; age range 25-48 years) and group 2 comprised 10 postmenopausal women (56 +/- 6.7 years; age range 49-72 years). The maximum standardized uptake value (SUVmax) was determined from the lumbar spine and the humeral shaft. Student%26apos;s t-test for each unpaired dataset was used to evaluate statistical differences between the two groups. The SUVmax values for the humeral shaft and the lumbar spine were compared with aging. %26lt;br%26gt;The SUVmax (mean +/- SD) was 1.2 +/- 0.5 in the humeral shaft and 4.7 +/- 1.0 in the lumbar spine. The SUVmax in the humeral shaft correlated significantly with advancing age (r = 0.67, P %26lt; 0.01). The SUVmax in the lumbar spine declined significantly with advancing age (r = -0.50, P %26lt; 0.01). The humeral shaft of women in group 1 exhibited a significantly lower SUVmax compared to that in group 2 (1.1 +/- 0.4 versus 1.6 +/- 0.6; P %26lt; 0.05). On the other hand, the lumbar spine of women in group 1 exhibited a significantly higher SUVmax compared to that in group 2 (5.1 +/- 0.7 versus 4.0 +/- 1.1; P %26lt; 0.05). The mean SUVmax in the lumbar spine was 2.5 times greater than that in the humeral shaft in group 2. %26lt;br%26gt;Semiquantitative analysis with F-18-fluoride PET might be a useful tool for analyzing age-related changes in pre- and postmenopausal women.

• 出版日期2012-8