Adverse Effects of Triclosan and Binary Mixtures with 17 beta-Estradiol on Testicular Development and Reproduction in Japanese Medaka (Oryzias latipes) at Environmentally Relevant Concentrations

作者：Wang, Chen; Li, Yu; Zheng, Guomao; Zhang, Shiyi; Wan, Yi; Hu, Jianying^*

来源：Environmental Science and Technology Letters, 2018, 5(3): 136-+.

DOI：10.1021/acs.estlett.8b00003

• GONADAL INTERSEX
• 3-SPINED STICKLEBACK
• FISH
• BEHAVIOR
• IDENTIFICATION
• ANTIANDROGEN
• CONTAMINANTS
• TRICLOCARBAN
• PHEROMONES
• EXPOSURE

Considering triclosan (TCS) is ubiquitous in surface water and wild fish at relatively high concentrations, its adverse effects on gonadal development and reproduction were evaluated. After exposure for 100 days after hatching, the lowest observable effective concentration (LOEC) of TCS to significantly induce gonadal intersex in male Japanese medaka (Oryzias latipes) was 117.9 ng/L. Courtship frequency and hatching rates in male medaka were significantly inhibited, and the LOECs of TCS to impact courtship frequency and hatching rates were 117.9 and 17.2 ng/L, respectively. Male medaka were also exposed to binary mixtures of 2.2 ng/L 17 beta-estradiol (beta E2) with 2.3 ng/L TCS and 2.4 ng/L beta E2 with 117.9 ng/L TCS, and a more severe intersex induction and depressed mating behavior compared to those seen after exposure to only beta E2 or TCS were observed. The adverse effects of TCS and binary mixtures with beta E2 on testicular development and reproduction in fish at environmentally relevant concentrations are demonstrated here for the first time.

• 出版日期2018-3
• 单位北京大学