Novel Phosphate Derivatives as Scaffolds for the Preparation of Synthetic Phosphoserine-Based Peptides Using the Fmoc/t-Bu Solid-Phase Strategy

作者：Cilibrizzi Agostino; Isidro Llobet Albert; Mateu Natalia; Galloway Warren R J D; Spring David R^*

来源：Synlett, 2012, (2): 290-294.

DOI：10.1055/s-0031-1290119

• phosphopeptide
• serine
• phosphorus
• solid-phase synthesis
• amino acids

Synthetic peptides incorporating analogues of phosphoserine are valuable tools for the study of protein kinases and phosphatases. In addition, derivatives of naturally occurring peptides incorporating phosphate groups may have interesting biological properties. Herein we describe a new Fmoc/t-Bu solid-phase peptide synthesis (SPPS) strategy for the convenient generation of phosphoserine-based peptides. A proof-of-concept synthesis that demonstrates the feasibility of this approach is presented.

• 出版日期2012-1